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4-amino-2-fluoro-N-methylbenzamide

Product Name
4-amino-2-fluoro-N-methylbenzamide
CAS No.
915087-25-1
Chemical Name
4-amino-2-fluoro-N-methylbenzamide
Synonyms
N-Methyl-2-fluoro-4-aminobenzamide;N-Methyl-4-amino-2-fluoro-benzamide;Enzalutamide ITS-3;Enzalutamide Impurity 40;Enzalutamide Impurity 20;4-AMINO-2-FLUORO-N-METHYLBENZAMIDE;4-amino-2-fluoro-N-menthylbenzamide;N-Methyl-2-fluoro-4-AminobenzoylAmine;2. 4-aMino-2-fluoro-N-MethylbenzaMide;BenzaMide, 4-aMino-2-fluoro-N-Methyl-
CBNumber
CB02452656
Molecular Formula
C8H9FN2O
Formula Weight
168.17
MOL File
915087-25-1.mol
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4-amino-2-fluoro-N-methylbenzamide Property

Melting point:
160 - 163°C
Boiling point:
320℃
Density 
1.234
Flash point:
147℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.12±0.46(Predicted)
color 
White to Off-White
Stability:
Moisture Sensitive
InChI
InChI=1S/C8H9FN2O/c1-11-8(12)6-3-2-5(10)4-7(6)9/h2-4H,10H2,1H3,(H,11,12)
InChIKey
XOKAXPQJUODMSH-UHFFFAOYSA-N
SMILES
C(NC)(=O)C1=CC=C(N)C=C1F
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Safety

HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Signal word
Warning
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N-Bromosuccinimide Price

TRC
Product number
A609743
Product name
4-​Amino-​2-​fluoro-​N-​methylbenzamide
Packaging
25g
Price
$275
Updated
2021/12/16
TRC
Product number
A609743
Product name
4-​Amino-​2-​fluoro-​N-​methylbenzamide
Packaging
50g
Price
$520
Updated
2021/12/16
AK Scientific
Product number
J95296
Product name
4-Amino-2-fluoro-N-methylbenzamide
Packaging
100g
Price
$520
Updated
2021/12/16
Matrix Scientific
Product number
143913
Product name
4-Amino-2-fluoro-N-methylbenzamide
Purity
95%
Packaging
25g
Price
$1110
Updated
2021/12/16
Matrix Scientific
Product number
143913
Product name
4-Amino-2-fluoro-N-methylbenzamide
Purity
95%
Packaging
5g
Price
$370
Updated
2021/12/16
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4-amino-2-fluoro-N-methylbenzamide Chemical Properties,Usage,Production

Uses

4-amino-2-fluoro-N-methylbenzamide acts as a reagent in the design, synthesis and biological evaluation of novel 5-oxo-2-thioxoimidazolidine derivatives as potent androgen receptor antagonists. Also, in the preparation and structure-activity relationship of chiral benzyloxypyridinone derivatives as c-Met kinase inhibitors.

Description

4-amino-2-fluoro-N-methylbenzamide is a novel antiandrogen drug MDV (Marek's Disease Virus) 3100 key intermediate which is the new generation oral androgen antagonist medicine of united states drug developer Medivation company exploitation, be mainly used in treating advanced prostate cancer (CRPC) patient.

Preparation

2-fluoro-4-nitrotoluene as raw material, through potassium permanganate oxidation, the thionyl chloride chlorination, methylamine amination, and Pd/C hydrogenation reduction prepare 4-amino-2-fluoro-N-methylbenzamide.

4-amino-2-fluoro-N-methylbenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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4-amino-2-fluoro-N-methylbenzamide Suppliers

Canada 1 China 204 India 15 Ukraine 1 United States 6 Global 227
Accela ChemBio Inc.
Tel
(+1)-858-699-3322
Fax
(+1)-858-876-1948
Email
info@accelachem.com
Country
United States
ProdList
19965
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14336
Advantage
58
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View Lastest Price from 4-amino-2-fluoro-N-methylbenzamide manufacturers

Wuhan Cell Pharmaceutical Co., Ltd
Product
4-AMINO-2-FLUORO-N-METHYLBENZAMIDE 915087-25-1
Price
US $9.90-454.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-03-30
Anhui Dexinjia Biopharm Co., Ltd
Product
N-Methyl-2-fluoro-4-aminobenzamide 915087-25-1
Price
US $15.00-50.00/kg
Min. Order
1kg
Purity
NLT98%
Supply Ability
5 ton per month
Release date
2023-09-19
Shanghai Joiny Pharmaceutical Co.,LTD
Product
N-Methyl-2-fluoro-4-aminobenzamide 915087-25-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
5500kg
Release date
2023-09-12

915087-25-1, 4-amino-2-fluoro-N-methylbenzamideRelated Search:

4-(2-CYANOPROPAN-2-YLAMINO)-2-FLUORO-N-METHYLBENZAMIDE 2-FLUORO-N-METHYL-4-NITROBENZAMIDE Enzalutamide Impurity 7 4-isothiocyanato-2-(trifluoroMethyl)benzonitrile Enzalutamide Impurity 7 4-[1-(4-cyano-3-trifluoromethyl-phenylcarbamoyl)-1-methyl-ethylamino]-2-fluoro-N- [2H6]-Enzalutamide N-desMethyl EnzalutaMide Enzalutamide carboxylic acid Methyl 4-bromo-2-fluorobenzoate Enzalutamide 4-[3-[4-Cyano-3-(trifluoroMethyl)phenyl]-5,5-diMethyl-4-oxo-2-thioxo-1-iMidazolidinyl]-2-fluoro-N-(Methyl-d3)benzaMide 4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl]-N-methylbenzamide 4-Bromo-2-fluorobenzoic acid methyl 2-fluoro-4-((1-methoxy-2-methyl-1-oxopropan-2-yl)amino)benzoate EnzalutaMide IMpurity Enzalutamide 4-[3-[4-Cyano-3-(trifluoromethyl)phenyl]-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl]-2-fluorobenzoic acid methyl ester

  • 4-AMINO-2-FLUORO-N-METHYLBENZAMIDE
  • N-Methyl-2-fluoro-4-aminobenzamide
  • BenzaMide, 4-aMino-2-fluoro-N-Methyl-
  • 2. 4-aMino-2-fluoro-N-MethylbenzaMide
  • N-Methyl-4-amino-2-fluoro-benzamide
  • 4-amino-2-fluoro-N-menthylbenzamide
  • Enzalutamide Impurity 20
  • Enzalutamide ITS-3
  • N-Methyl-2-fluoro-4-AminobenzoylAmine
  • Enzalutamide Impurity 40
  • 915087-25-1
  • 915087-25-1